The drug discovery process is a rocky path that is full of challenges, with the result that very
few candidates progress from hit compound to a commercially available product, often due …

A pharmacophore describes the framework of molecular features that are vital for the
biological activity of a compound. Pharmacophore models are built by using the structural …

The flame retardants hexabromobenzene (HBB) and pentabromobenzene (PBB) have been
extensively used and become ubiquitous pollutants in the aquatic environment and biota …

Bis (2-ethylhexyl) tetrabromophthalate (TBPH) has been widely detected in the environment
and organisms; thus, its toxic effects on male reproduction were systematically studied. First …

Licorice flavonoids (LCFs) have been widely used in food care and medical treatment due to
their significant antioxidant activities. However, the molecular mechanism of their antioxidant …

Bis (2-ethylhexyl)-2, 3, 4, 5-tetrabromophthalate (TBPH) is a ubiquitous environmental
contaminant, but its toxicity is not fully understood. Accordingly, we investigated the effects of …

Deltamethrin, a widely used type II pyrethroid insecticide, was reported with neurotoxicity to
aquatic organisms, such as fish. However, the effects and potential mechanisms on the …

Licorice flavonoids (LCFs) are natural flavonoids isolated from Glycyrrhiza which are known
to have anti-melanoma activities in vitro. However, the molecular mechanism of LCF anti …

The pivotal role of MRP3 protein in acute leukaemia and the efficacy of natural compounds
in cancer treatment have necessitated the current study to identify novel MRP3 inhibitors …

Pyridine is a nitrogen bearing heterocyclic scaffold that shows a wide range of biological
activities. The pyridine nucleus has become an interesting target for medicinal chemistry …