A key player in driving cellular immunity, IFN-γ is capable of orchestrating numerous
protective functions to heighten immune responses in infections and cancers. It can exhibit …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Recognition of microbial pathogens and dead cells and their phagocytic uptake by
specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo …

The principal components of both MHC class I and class II antigen processing and
presentation pathways are well known. In dendritic cells, these pathways are tightly …

Phagosome maturation is the process by which internalized particles (such as bacteria and
apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound …

Lysosomes are organelles of eukaryotic cells that are critically involved in the degradation of
macromolecules mainly delivered by endocytosis and autophagocytosis. Degradation is …

This review focuses on the sequence of cellular events leading to calcium signals critical for
phagosome maturation. Immune cells kill microbes by engulfing them in a membrane …

The ability of macrophages to clear pathogens and elicit a sustained immune response is
regulated by various cytokines, including interferon-γ (IFN-γ). To investigate the molecular …

Professional phagocytes ingest particulate material to fulfil a diverse array of functions in a
multicellular organism. The ancestral function of phagosomes is digestion; however, through …

Originally identified by their unusual ability to bind guanosine monophosphate (GMP)
nucleotide agarose, the guanylate-binding proteins (GBPs) were used extensively to …