Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …

Mitochondria are highly dynamic organelles whose functions are essential for cell viability.
Within the cell, the mitochondrial network is continuously remodeled through the balance …

Acute kidney injury (AKI) has been widely recognized as an important risk factor for the
occurrence and development of chronic kidney disease (CKD). Even milder AKI has adverse …

Excessive vanadium (V) contamination is an attracting growing concern, which can
negatively affect the health of human and ecosystems. But how V causes nephrotoxicity and …

Autophagy is a process of intracellular self-recycling and degradation that plays an
important role in maintaining cell homeostasis. However, the molecular mechanism of …

Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition
of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its …

Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …

The integrity of ER–mitochondria appositions ensures transfer of ions and phospholipids
(PLs) between these organelles and exerts crucial effects on mitochondrial bioenergetics …

Obesity challenges lipid and carbohydrate metabolism. The resulting glucolipotoxicity
causes endoplasmic reticulum (ER) dysfunction, provoking the accumulation of immature …

In the sanctity of pure drug discovery, objective reasoning can become clouded when
pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into …