Recent advances in models, mechanisms, biomarkers, and interventions in cisplatin-induced acute kidney injury
SJ Holditch, CN Brown, AM Lombardi… - International journal of …, 2019 - mdpi.com
Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …
Aging and its treatment with vitamin C: a comprehensive mechanistic review
S Mumtaz, S Ali, HM Tahir, SAR Kazmi… - Molecular biology …, 2021 - Springer
Aging and age-related disorders have become one of the prominent issue of world.
Oxidative stress due to overproduction of reactive oxygen species is the most significant …
Oxidative stress due to overproduction of reactive oxygen species is the most significant …
NLRP3 inflammasome in rosmarinic acid-afforded attenuation of acute kidney injury in mice
Cisplatin (CP) is a well-known anticancer drug used to effectively treat various kinds of solid
tumors. CP causes acute kidney injury (AKI) and unfortunately, there is no therapeutic …
tumors. CP causes acute kidney injury (AKI) and unfortunately, there is no therapeutic …
Tempol reverses the negative effects of morphine on arterial blood-gas chemistry and tissue oxygen saturation in freely-moving rats
SM Baby, JF Discala, R Gruber, PM Getsy… - Frontiers in …, 2021 - frontiersin.org
We have reported that pretreatment with the clinically approved superoxide dismutase
mimetic, Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine-N-oxyl), blunts the …
mimetic, Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine-N-oxyl), blunts the …
Renal arterial infusion of tempol prevents medullary hypoperfusion, hypoxia, and acute kidney injury in ovine gram‐negative sepsis
Aim Renal medullary hypoperfusion and hypoxia precede acute kidney injury (AKI) in ovine
sepsis. Oxidative/nitrosative stress, inflammation, and impaired nitric oxide generation may …
sepsis. Oxidative/nitrosative stress, inflammation, and impaired nitric oxide generation may …
Systemic administration of tempol attenuates the cardiorespiratory depressant effects of fentanyl
S Baby, R Gruber, J Discala, V Puskovic… - Frontiers in …, 2021 - frontiersin.org
Fentanyl is a high-potency opioid receptor agonist that elicits profound analgesia and
suppression of breathing in humans and animals. To date, there is limited evidence as to …
suppression of breathing in humans and animals. To date, there is limited evidence as to …
Beneficial effect of tempol, a membrane-permeable radical scavenger, on inflammation and osteoarthritis in in vitro models
G Calabrese, A Ardizzone, M Campolo, S Conoci… - Biomolecules, 2021 - mdpi.com
Osteoarthritis (OA) is one of the most common and widespread diseases which is highly
disabling for humans. This makes OA a chronic disease for which it is urgent to find new …
disabling for humans. This makes OA a chronic disease for which it is urgent to find new …
Oxidative Stress, Inflammation, and Activators of Mitochondrial Biogenesis: Tempol Targets in the Diaphragm Muscle of Exercise Trained-mdx Mice
HNM Silva, C Covatti, GL Rocha, DS Mizobuti… - Frontiers in …, 2021 - frontiersin.org
The mdx mouse phenotype aggravated by chronic exercise on a treadmill makes this murine
model more reliable for the study of muscular dystrophy. Thus, to better assess the Tempol …
model more reliable for the study of muscular dystrophy. Thus, to better assess the Tempol …
Nitronyl Nitroxide Ameliorates Hypobaric Hypoxia-Induced Cognitive Impairment in Mice by Suppressing the Oxidative Stress, Inflammatory Response and Apoptosis
L Jing, Q Da, S Zhang, J Zhang, H Ma, H Luo - Neurochemical Research, 2024 - Springer
Abundant investigations have shown that hypobaric hypoxia (HH) causes cognitive
impairment, mostly attributed to oxidative stress, inflammation, and apoptosis. HPN (4 …
impairment, mostly attributed to oxidative stress, inflammation, and apoptosis. HPN (4 …
Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized …
B Liu, Y Hu, D Tian, J Dong, BF Li - BMC nephrology, 2024 - Springer
Background Oxidative stress has been implicated in the pathogenesis of chronic kidney
disease (CKD), prompting the exploration of antioxidants as a potential therapeutic avenue …
disease (CKD), prompting the exploration of antioxidants as a potential therapeutic avenue …