The language of chromatin modification in human cancers
The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …
subjected to DNA methylation and various histone modifications. Such a 'language'of …
Writing, erasing and reading histone lysine methylations
Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …
many cellular events. Lysine methylations mark various sites on the tail and globular …
MLL-rearranged leukemias—an update on science and clinical approaches
AC Winters, KM Bernt - Frontiers in pediatrics, 2017 - frontiersin.org
The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
Mll3 and Mll4 facilitate enhancer RNA synthesis and transcription from promoters independently of H3K4 monomethylation
KM Dorighi, T Swigut, T Henriques, NV Bhanu… - Molecular cell, 2017 - cell.com
Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …
WD40 repeat domain proteins: a novel target class?
M Schapira, M Tyers, M Torrent… - Nature reviews Drug …, 2017 - nature.com
Antagonism of protein–protein interactions (PPIs) with small molecules is becoming more
feasible as a therapeutic approach. Successful PPI inhibitors tend to target proteins …
feasible as a therapeutic approach. Successful PPI inhibitors tend to target proteins …
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
W Qi, K Zhao, J Gu, Y Huang, Y Wang, H Zhang… - Nature chemical …, 2017 - nature.com
Abstract Polycomb repressive complex 2 (PRC2) consists of three core subunits, EZH2, EED
and SUZ12, and plays pivotal roles in transcriptional regulation. The catalytic subunit EZH2 …
and SUZ12, and plays pivotal roles in transcriptional regulation. The catalytic subunit EZH2 …
Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
Summary Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
Chemical and biochemical perspectives of protein lysine methylation
M Luo - Chemical reviews, 2018 - ACS Publications
Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …
Structural basis of nucleosome recognition and modification by MLL methyltransferases
H Xue, T Yao, M Cao, G Zhu, Y Li, G Yuan, Y Chen… - Nature, 2019 - nature.com
Methyltransferases of the mixed-lineage leukaemia (MLL) family—which include MLL1,
MLL2, MLL3, MLL4, SET1A and SET1B—implement methylation of histone H3 on lysine 4 …
MLL2, MLL3, MLL4, SET1A and SET1B—implement methylation of histone H3 on lysine 4 …