With a worldwide prevalence of 15%, chronic constipation is one of the most frequent
gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source …

Background: Chronic constipation is described as a common complication determined by
difficult and/or rare passage of stool or both. The difference in definition of constipation has …

Chronic constipation is a prevalent condition that severely impacts the quality of life of those
affected. Several types of primary chronic constipation, which show substantial overlap …

OBJECTIVES: Chronic idiopathic constipation (CIC) is a common functional gastrointestinal
disorder in the community, yet no previous systematic review and meta-analysis has …

We aimed to review the published literature regarding the epidemiology of constipation in
the general paediatric and adult population and to assess its geographic, gender and age …

Background: Functional constipation is a prevalent, burdensome gastrointestinal disorder
whose treatment remains challenging. Probiotics have been increasingly investigated in its …

Aliment Pharmacol Ther 31, 938–949 Summary Background Comparison of quality of life
(QoL) across disease areas requires the use of appropriate tools. Although many studies …

Background Although constipation can be a chronic and severe problem, it is largely treated
empirically. Evidence for the efficacy of some of the older laxatives from well‐designed trials …

Background There has been no definitive systematic review and meta-analysis to date
examining the effect of laxatives and pharmacological therapies in chronic idiopathic …

Background Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C
receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients …