The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …

Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …

Cancer-specific T cells are required for effective anti-cancer immunity and have a central
role in cancer immunotherapy. However, emerging evidence suggests that only a small …

Background & Aims Despite recent translation of immunotherapies into clinical practice, the
immunobiology of hepatocellular carcinoma (HCC), in particular the role and clinical …

Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC),
yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both …

Objective A comprehensive immune landscape for HBV infection is pivotal to achieve HBV
cure. Design We performed single-cell RNA sequencing of 2 43 000 cells from 46 paired …

T cells are at the center of cancer immunology because of their ability to recognize mutations
in tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate …

The liver's unique characteristics have a profound impact on the priming and maintenance of
adaptive immunity. This review delves into the cellular circuits that regulate adaptive …