An overview of advancement of organoruthenium (II) complexes as prospective anticancer agents
The successful clinical translation of platinum drugs for cancer treatment has witnessed an
upsurge in the development of metal compounds as therapeutics and diagnostics drugs …
upsurge in the development of metal compounds as therapeutics and diagnostics drugs …
Group 9 organometallic compounds for therapeutic and bioanalytical applications
DL Ma, DSH Chan, CH Leung - Accounts of chemical research, 2014 - ACS Publications
Conspectus Compared with organic small molecules, metal complexes offer several distinct
advantages as therapeutic agents or biomolecular probes. Carbon atoms are typically …
advantages as therapeutic agents or biomolecular probes. Carbon atoms are typically …
Cyclometalated iridium (III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents
Stimuli-activatable photosensitizers (PSs) are highly desirable for photodynamic therapy
(PDT) to selectively demolish tumor cells. On the other hand, lysosomes are emerging as …
(PDT) to selectively demolish tumor cells. On the other hand, lysosomes are emerging as …
Rhodium (III)–Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy
YQ Gu, K Yang, QY Yang, HQ Li, MQ Hu… - Journal of Medicinal …, 2023 - ACS Publications
As a continuation of our endeavors in discovering metal-based drugs with cytotoxic and
antimetastatic activities, herein, we reported the syntheses of 11 new rhodium (III) …
antimetastatic activities, herein, we reported the syntheses of 11 new rhodium (III) …
Electrochemical NADH Regeneration Mediated by Pyridine Amidate Iridium Complexes Interconverting 1, 4-and 1, 6-NADH
Although there is a huge interest in redox mediators for the selective electrochemical
regeneration of 1, 4-NADH, only the class of rhodium compounds with bipyridine ligands …
regeneration of 1, 4-NADH, only the class of rhodium compounds with bipyridine ligands …
Half-Sandwich Iridium(III), Rhodium(III), and Ruthenium(II) Complexes Chelating Hybrid sp2-N/sp3-N Donor Ligands to Achieve Improved Anticancer Selectivity
L Guo, P Li, J Li, Y Gong, X Li, Y Liu, K Yu… - Inorganic …, 2023 - ACS Publications
The biological efficacy of half-sandwich platinum group organometallic complexes of the
formula [(η5-Cpx)/(η6-arene) M (XY) Cl] 0/+(XY= bidentate ligands; Cpx= functionalized …
formula [(η5-Cpx)/(η6-arene) M (XY) Cl] 0/+(XY= bidentate ligands; Cpx= functionalized …
Construction of homo and heteronuclear Ru (II), Ir (III) and Re (I) complexes for target specific cancer therapy
More than 10 million death tolls in 2020 were reported as a result of heinous impact of
cancer, making it second most prime cause of death after cardiovascular diseases. In …
cancer, making it second most prime cause of death after cardiovascular diseases. In …
Single-Site Iridium Picolinamide Catalyst Immobilized onto Silica for the Hydrogenation of CO2 and the Dehydrogenation of Formic Acid
The development of an efficient heterogeneous catalyst for storing H2 into CO2 and
releasing it from the produced formic acid, when needed, is a crucial target for overcoming …
releasing it from the produced formic acid, when needed, is a crucial target for overcoming …
Intracellular transfer hydrogenation mediated by unprotected organoiridium catalysts
In the present work, we show for the first time that the conversion of aldehydes to alcohols
can be achieved using “unprotected” iridium transfer hydrogenation catalysts inside living …
can be achieved using “unprotected” iridium transfer hydrogenation catalysts inside living …
Iridium (III) complexes targeting apoptotic cell death in cancer cells
DL Ma, C Wu, KJ Wu, CH Leung - Molecules, 2019 - mdpi.com
Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years,
non-platinum-based scaffolds have been exploited as viable candidates for the exploitation …
non-platinum-based scaffolds have been exploited as viable candidates for the exploitation …