We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

TRPV1 is a nonselective cation channel vital for detecting noxious stimuli (heat, acid,
capsaicin). Its role in pain makes it a potential drug target for chronic pain management …

As a member of the transient receptor potential (TRP) channels superfamily, the TRPV1
channel undergoes a closed-to-open gating transition in response to various physical and …

Transient receptor potential vanilloid (TRPV) channels are part of the superfamily of TRP ion
channels and play important roles in widespread physiological processes including both …

Local anesthetics are weak bases and alter their properties in accordance with their
protonation state, which depends on the environmental pH. We studied the transport …

The optical control and investigation of neuronal activity can be achieved and carried out
with photoswitchable ligands. Such compounds are designed in a modular fashion …

Significant computational efforts have been focused toward exposing the molecular
mechanisms of anesthesia in recent years. In the past decade, this has been aided …

Transient receptor potential (TRP) channels are cation channels that regulate key
physiological and pathological processes in response to a broad range of stimuli. Moreover …

Abstract Background Volatile anaesthetics (VAs) are the most widely used compounds to
induce reversible loss of consciousness and maintain general anaesthesia during surgical …

Several varieties of chili peppers are produced and consumed in practically all of Brazil (DE
CARVALHO et al., 2006), being in third place among the vegetables most used as …