Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs

G Bolla, B Sarma, AK Nangia - Chemical reviews, 2022 - ACS Publications
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

The halogen bond

G Cavallo, P Metrangolo, R Milani, T Pilati… - Chemical …, 2016 - ACS Publications
The halogen bond occurs when there is evidence of a net attractive interaction between an
electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic …

Pharmaceutical cocrystals: along the path to improved medicines

NK Duggirala, ML Perry, Ö Almarsson… - Chemical …, 2016 - pubs.rsc.org
Cocrystals, a long known but understudied class of crystalline solids, have attracted interest
from crystal engineers and pharmaceutical scientists in the past decade and are now an …

Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design

DJ Berry, JW Steed - Advanced drug delivery reviews, 2017 - Elsevier
As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges

PC Vioglio, MR Chierotti, R Gobetto - Advanced Drug Delivery Reviews, 2017 - Elsevier
In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

Halogen bonding beyond crystals in materials science

M Saccone, L Catalano - The Journal of Physical Chemistry B, 2019 - ACS Publications
Halogen bonding has recently gained well deserved attention in present-day research for its
importance in many fields of supramolecular science and crystal engineering. Although …

Supramolecular Hierarchy among Halogen‐Bond Donors

CB Aakeröy, M Baldrighi, J Desper… - … A European Journal, 2013 - Wiley Online Library
Through a combination of structural chemistry, vibrational spectroscopy, and theory, we
have systematically examined the relative structure‐directing importance of a series of …

Unravelling the potential of sigma hole-assisted co-crystallization: Highlighting recent developments

R Siddiqui, J Rani, HM Titi, R Patra - Coordination Chemistry Reviews, 2024 - Elsevier
In the past several decades, the field of cocrystal engineering has developed into a vital
research topic in supramolecular chemistry, holding the foremost scope in crystal …

Definition of the Halogen Bond (IUPAC Recommendations 2013): A Revisit

PR Varadwaj, A Varadwaj, HM Marques… - Crystal Growth & …, 2024 - ACS Publications
This Article revisits the “Definition of the Halogen Bond (IUPAC Recommendations
2013)”[Desiraju, GR Pure Appl. Chem. 2013, 85 (8), 1711–1713], recommendations that fail …

Dramatically Enhanced Solubility of Halide‐Containing Organometallic Species in Diiodomethane: The Role of Solvent⋅⋅⋅ Complex Halogen Bonding

MA Kinzhalov, MV Kashina, AS Mikherdov… - Angewandte …, 2018 - Wiley Online Library
In the current study, we evaluated the solubility of a number of organometallic species and
showed that it is noticeably improved in diiodomethane when compared to other haloalkane …