Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

BACKGROUND The defining feature of eukaryotic cells is the presence of membrane-bound
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …

The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …

Close proximities between organelles have been described for decades. However, only
recently a specific field dealing with organelle communication at membrane contact sites …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The understanding that organelles are not floating in the cytosol, but rather held in an
organized yet dynamic interplay through membrane contact sites, is altering the way we …

Eukaryotic cells are organized into membrane-bound organelles. These organelles
communicate with one another through vesicular trafficking pathways and membrane …

Lysosomes are of major importance for the regulation of cellular cholesterol homeostasis.
Food-derived cholesterol and cholesterol esters contained within lipoproteins are delivered …

Many cellular redox reactions housed within mitochondria, peroxisomes and the
endoplasmic reticulum (ER) generate hydrogen peroxide (H2O2) and other reactive oxygen …

Physical contact between organelles is vital to the function of eukaryotic cells. Lipid droplets
(LDs) are dynamic organelles specialized in lipid storage that interact physically with …