Sirtuins are a conserved family of proteins found in all domains of life. The first known sirtuin,
Sir2 (silent information regulator 2) of Saccharomyces cerevisia e, from which the family …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

Fetal hemoglobin (HbF, α 2 γ 2) level is genetically controlled and modifies severity of adult
hemoglobin (HbA, α 2 β 2) disorders, sickle cell disease, and β-thalassemia. Common …

β-Thalassemia and sickle cell disease both display a great deal of phenotypic
heterogeneity, despite being generally thought of as simple Mendelian diseases. The …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that
accounts for substantial phenotypic diversity of sickle cell disease and β thalassemia. We …

Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-
dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a …

Resveratrol, a red wine polyphenol, is known to protect against cardiovascular diseases and
cancers, as well as to promote antiaging effects in numerous organisms. It also modulates …

Sirtuins comprise a family of NAD+-dependent protein deacetylases and ADP-
ribosyltransferases. Mammalian SIRT1–a homolog of yeast Sir2, the prototypical member of …

The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates
lifespan in multiple organisms, down-regulates p53 function through deacetylation, and is …