MicroRNAs (miRNAs) are small regulatory molecules post-transcriptionally suppressing
mRNA activity. Many miRNAs in various organisms have been cloned but many unknown …

The term 'diabetes distress' first entered the psychosocial research vernacular in 1995, and
refers to 'the negative emotional or affective experience resulting from the challenge of living …

OBJECTIVE: To design a functional, patient-centered model of patient complexity with
practical applicability to analytic design and clinical practice. Existing literature on patient …

Background In this article we outline Burden of Treatment Theory, a new model of the
relationship between sick people, their social networks, and healthcare services. Health …

Importance There is substantial uncertainty about optimal glycemic control in older adults
with type 2 diabetes mellitus. Observations Four large randomized clinical trials (RCTs) …

Objective To explore medication-related burden (MRB) and patients' lived experience with
medicines (PLEM) without regard to particular medication therapies or medical conditions …

Across the world healthcare systems are struggling to cope with increasing demands and
costs. Rising life expectancy has been accompanied by an explosion in the prevalence of …

Objective To synthesize existing qualitative literature on patient-experienced burden of
treatment in multimorbid patients. Methods A literature search identified available qualitative …

Background Management strategies for patients with chronic conditions are becoming
increasingly complex, which may result in a burden of treatment for patients. To develop a …

Background Treatment burden refers to the workload imposed by healthcare on patients,
and the effect this has on quality of life. The Treatment Burden Questionnaire (TBQ) aims to …