Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene
encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT …

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function
heterozygous mutations of methyl CpG-binding protein 2 (MECP2) on the X chromosome in …

Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

Rare diseases are very difficult to study mechanistically and to develop therapies for
because of the scarcity of patients. Here, the rare neuro-metabolic disorder Rett syndrome …

Neurological and neuropsychiatric disorders affect men and women differently. Multiple
sclerosis, Alzheimer's disease, anxiety disorders, depression, meningiomas and late-onset …

The X-chromosome harbors hundreds of disease genes whose associated diseases
predominantly affect males. However, a subset, including neurodevelopmental disorders …

Pulmonary arterial hypertension (PAH) is a rare cardiovascular disorder leading to
pulmonary hypertension and, often fatal, right heart failure. Sex differences in PAH are …

A tribute to Mary Lyon was held in October 2016. Many remarked about Lyon's foresight
regarding many intricacies of the X-chromosome inactivation process. One such example is …

Sexual dimorphism has been reported in various human diseases including autoimmune
diseases, neurological diseases, pulmonary arterial hypertension, and some types of …