Improved vaccine against PRRSV: current progress and future perspective

Y Nan, C Wu, G Gu, W Sun, YJ Zhang… - Frontiers in …, 2017 - frontiersin.org
Porcine reproductive and respiratory syndrome virus (PRRSV), one of the most
economically significant pathogens worldwide, has caused numerous outbreaks during the …

Antiviral strategies against PRRSV infection

T Du, Y Nan, S Xiao, Q Zhao, EM Zhou - Trends in microbiology, 2017 - cell.com
PRRSV (porcine reproductive and respiratory syndrome virus) is a major economically
significant pathogen that has adversely impacted the global swine industry for almost 30 …

Porcine reproductive and respiratory syndrome virus reverse genetics and the major applications

J Chaudhari, HLX Vu - Viruses, 2020 - mdpi.com
Porcine reproductive and respiratory syndrome virus (PRRSV) is a positive sense, single-
stranded RNA virus that is known to infect only pigs. The virus emerged in the late 1980s …

Structural characterization of non-structural protein 9 complexed with specific nanobody pinpoints two important residues involved in porcine reproductive and …

Y Wang, R Li, S Qiao, J Wang, H Liu, Z Li… - Frontiers in …, 2020 - frontiersin.org
Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV), is
a widespread viral disease that has led to huge economic losses for the global swine …

Development of a broadly protective modified-live virus vaccine candidate against porcine reproductive and respiratory syndrome virus

H Sun, A Workman, FA Osorio, D Steffen, HLX Vu - Vaccine, 2018 - Elsevier
Modified-live virus (MLV) vaccines are widely used to protect pigs against porcine
reproductive and respiratory syndrome virus (PRRSV). However, current MLV vaccines do …

Testable candidate immune correlates of protection for porcine reproductive and respiratory syndrome virus vaccination

AR Kick, AF Grete, E Crisci, GW Almond, T Käser - Vaccines, 2023 - mdpi.com
Porcine reproductive and respiratory syndrome virus (PRRSV) is an on-going problem for
the worldwide pig industry. Commercial and experimental vaccinations often demonstrate …

Interleukin-21 enhances the antibody avidity elicited by DNA prime and MVA boost vaccine

W Fan, Y Wan, Q Li - Cytokine, 2020 - Elsevier
Enhancement of the magnitude or affinity of protective antibodies (Abs) induced by vaccine
adjuvant is highly desirable to prevent challenging pathogens such as HIV-1. IL-21 plays a …

Host transcriptional response to persistent infection with a live-attenuated porcine reproductive and respiratory syndrome virus strain

J Chaudhari, CS Liew, AM Workman, JJM Riethoven… - Viruses, 2020 - mdpi.com
Both virulent and live-attenuated porcine reproductive and respiratory syndrome virus
(PRRSV) strains can establish persistent infection in lymphoid tissues of pigs. To investigate …

The middle half genome of interferon-inducing porcine reproductive and respiratory syndrome virus strain A2MC2 is essential for interferon induction

Z Ma, Y Yu, Y Xiao, T Opriessnig… - Journal of General …, 2017 - microbiologyresearch.org
Porcine reproductive and respiratory syndrome virus (PRRSV) is known to antagonize the
innate immune response. An atypical PRRSV strain A2MC2 is capable of inducing synthesis …

Novel Insights into Porcine Reproductive and Respiratory Syndrome Virus Host-Pathogen Interactions

J Chaudhari - 2022 - search.proquest.com
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most significant
swine viral pathogens worldwide. The lack of effective and broadly protective vaccines …