Recent advances in medicinal chemistry of oleanolic acid derivatives

YH Yang, SY Dai, FH Deng, LH Peng, C Li, YH Pei - Phytochemistry, 2022 - Elsevier
Oleanolic acid (OA), a ubiquitous pentacyclic oleanane-type triterpene isolated from edible
and medicinal plants, exhibits a wide spectrum of pharmacological activities and …

Recent advances in the chemistry and biology of oleanolic acid and its derivatives

N Verma, DS Raghuvanshi, RV Singh - European Journal of Medicinal …, 2024 - Elsevier
The pentacyclic triterpenes represent a significant class of plant bioactives with a variety of
structures and a wide array of biological activities. These are biosynthetically produced via …

Anti-Inflammatory Activity of Three Triterpene from Hippophae rhamnoides L. in Lipopolysaccharide-Stimulated RAW264.7 Cells

Y Han, C Yuan, X Zhou, Y Han, Y He, J Ouyang… - International Journal of …, 2021 - mdpi.com
Oleanolic acid (OA), asiatic acid (AA), and maslinic acid (MA) are ubiquitous isomeric
triterpene phytochemicals with many pharmacological effects. To improve their application …

Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory …

AI Sayed, YE Mansour, MA Ali, O Aly… - Journal of Enzyme …, 2022 - Taylor & Francis
Current medical approaches to control the Covid-19 pandemic are either to directly target
the SARS-CoV-2 via innovate a defined drug and a safe vaccine or indirectly target the …

[HTML][HTML] Principal Bioactive Properties of Oleanolic Acid, Its Derivatives, and Analogues

F Jannus, J Sainz, FJ Reyes-Zurita - Molecules, 2024 - mdpi.com
Natural products have always played an important role in pharmacotherapy, helping to
control pathophysiological processes associated with human disease. Thus, natural …

Semisynthesis and Evaluation of Anti-Inflammatory Activity of the Cassane-Type Diterpenoid Taepeenin F and of Some Synthetic Intermediates

H Zentar, F Jannus, P Gutierrez… - Journal of Natural …, 2022 - ACS Publications
A new strategy for the semisynthesis of the aromatic cassane-type diterpene taepeenin F (6)
is reported. The introduction of the methyl group at C-14, characteristic of the target …

Synthesis and preliminary cytotoxicity evaluation of water soluble pentacyclic triterpenoid phosphonates

J Lugiņina, V Kroškins, R Lācis, E Fedorovska… - Scientific Reports, 2024 - nature.com
Synthesis, solubility and cytotoxicity evaluation of anionic phosphonates derived from
betulin, betulinic acid, oleanolic acid and ursolic acid is reported. Phosphonate moieties …

A review of structural modification and biological activities of oleanolic acid

Y Huali, D Minghui, JIA Hongwei, K Zhang… - Chinese Journal of …, 2024 - Elsevier
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits a broad spectrum of biological
activities, including antitumor, antiviral, antibacterial, anti-inflammatory, hepatoprotective …

Acetylation of Oleanolic Acid Dimers as a Method of Synthesis of Powerful Cytotoxic Agents

A Günther, P Zalewski, S Sip, P Ruszkowski… - Molecules, 2024 - mdpi.com
Oleanolic acid, a naturally occurring triterpenoid compound, has garnered significant
attention in the scientific community due to its diverse pharmacological properties …

Synthesis, pharmacological and molecular docking investigations of 1, 3, 4-oxadiazole-5-thionyl derivatives of extracted cis-clerodane diterpenoid from Cistus …

FI Mahi, MA Mehdid, H Zentar, AA Othman… - Medicinal Chemistry …, 2023 - Springer
Two main products namely 18-hydroxy-cis-clerodan-3-ene-15-oic acid and 18-acetoxy-cis-
clerodan-3-ene-15-oic acid were isolated from the extract of the plant Cistus monspeliensis …