There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …

Fe (II)/α-ketoglutarate (αKG)-dependent hydroxylases catalyze an amazing diversity of
reactions that result in protein side-chain modifications, repair of alkylated DNA/RNA …

Fluorochemicals are a widely distributed class of compounds and have been utilized across
a wide range of industries for decades. Given the environmental toxicity and adverse health …

Cellular DNA is constantly subjected to modifications by intracellular and extracellular
chemicals, which can result in covalent changes. 1, 2 Alkylating agents are one group of …

Density functional calculations on the oxygenation reaction of propene by a model for
taurine/α-ketoglutarate dioxygenase (TauD) enzyme are presented. The oxo-iron active …

Advances in bioinorganic chemistry since the 1970s have been driven by three factors: rapid
determination of high-resolution structures of proteins and other biomolecules, utilization of …

The iron (ii)‐and α‐ketoglutarate‐dependent dioxygenases comprise enzymes that catalyze
a variety of important reactions in biology, including steps in the biosynthesis of collagen …

This review examines the mechanisms propelling cofactor-independent, organic cofactor-
dependent and metal-dependent decarboxylase chemistry. Decarboxylation, the removal of …

The final step in the biosynthesis of the plant signaling molecule ethylene is catalyzed by 1-
aminocyclopropane-1-carboxylic acid oxidase (ACCO). ACCO requires bicarbonate as an …

Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-
methyladenine and 3-methylcytosine in nucleic acids via an oxidative mechanism that …