Abstract Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to
endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that …

Regulated exocytosis is the main mechanism utilized by specialized secretory cells to
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …

The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

The vascular environment can rapidly alter, and the speed with which responses to both
physiological and pathological changes are required necessitates the existence of a highly …

Chemokines presented by the endothelium are critical for integrin-dependent adhesion and
transendothelial migration of naive and memory lymphocytes. Here we found that effector …

The chemokine CXCL12 is essential for the function of hematopoietic stem and progenitor
cells. Here we report that secretion of functional CXCL12 from human bone marrow stromal …

It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …

Are the dimer structures of active Ras isoforms similar? This question is significant since Ras
can activate its effectors as a monomer; however, as a dimer, it promotes Raf's activation …

Abstract The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the
Ras superfamily of small GTPases. Research on Ral GTPases and their functions over the …

Ras proteins function as molecular switches that are activated in response to signalling
pathways initiated by various extracellular stimuli and subsequently bind to numerous …