Central neuropathic pain arises from a lesion or disease of the central somatosensory
nervous system such as brain injury, spinal cord injury, stroke, multiple sclerosis or related …

Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the
brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the …

The blood-brain barrier (BBB) plays central roles in the maintenance and health of the brain.
Its mechanisms to safeguard the brain against xenobiotics and endogenous toxins also …

Homeostatic plasticity maintains the stability of functional brain networks. The axon initial
segment (AIS), where action potentials start, undergoes dynamic adjustment to exert …

The adeno-associated virus (AAV) is a defective single-stranded DNA virus with the simplest
structure reported to date. It constitutes a capsid protein and single-stranded DNA. With its …

Introduction The blood–brain barrier (BBB) restricts brain access of virtually all
macromolecules. Receptor-mediated transcytosis (RMT) is one strategy toward their brain …

Anxiety disorders are a leading source of human misery, morbidity, and premature mortality.
Existing treatments are far from curative for many, underscoring the need to clarify the …

Advancing our understanding of brain function and developing treatments for neurological
diseases hinge on the ability to modulate neuronal groups in specific brain areas without …

Today, adeno-associated virus (AAV)-based vectors are arguably the most promising in vivo
gene delivery vehicles for durable therapeutic gene expression. Advances in molecular …

Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a
hallmark of most CNS disorders. The transformative potentials of recently approved gene …