High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …

The original COVID-19 vaccines, developed against SARS-CoV-2, initially mitigated
hospitalizations. Bivalent vaccine boosters were used widely during 2022–23, but the …

The drug discovery and research for an anti-COVID-19 drug has been ongoing despite
repurposed drugs in the market. Over time, these drugs were discontinued due to side …

Drug repurposing refers to the inference of therapeutic relationships between a clinical
indication and existing compounds. As an emerging paradigm in drug development, drug …

NSP16 is one of the structural proteins of the severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) necessary for its entrance to the host cells. It exhibits 2'O-methyl …

This paper discusses the issue of overriding the right of individual consent to participation in
cluster randomised trials (CRTs). We focus on CRTs testing the efficacy of non …

Conflicting results undermine making inferences from the empirical literature. So far, the
replication crisis is mainly seen as resulting from honest errors and questionable research …

Drug repurposing is a strategy of identifying new potential uses for already existing drugs.
Many researchers adopted this method to identify treatment or prevention during the COVID …

Partisan conflict over the efficacy of repurposed drugs emerged as one of most divisive
elements of the highly politicized response to the COVID-19 pandemic. This dispute …

Research is a vital part of the effective response to a disease outbreak. Given the wide
spectrum of potential outbreaks and the varying therapeutic research questions, it is …