Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
Role of JAK/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial–mesenchymal transition
W Jin - Cells, 2020 - mdpi.com
The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders
Leukocyte migration from the vascular compartment is critical for normal lymphocyte
recirculation in specific tissues and immune response in inflammatory locations. Leukocyte …
recirculation in specific tissues and immune response in inflammatory locations. Leukocyte …
miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche
B Li, Y Xia, J Lv, W Wang, Z Xuan, C Chen, T Jiang… - Oncogene, 2021 - nature.com
Liver metastasis (LM) severely affects gastric cancer (GC) patients' prognosis. Small
extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV …
extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV …
LncRNA RUNX1-IT1 which is downregulated by hypoxia-driven histone deacetylase 3 represses proliferation and cancer stem-like properties in hepatocellular …
L Sun, L Wang, T Chen, Y Shi, B Yao, Z Liu… - Cell death & …, 2020 - nature.com
Hepatocellular carcinoma (HCC) is characterised by a hypoxic microenvironment and a high
rate of heterogeneity and recurrence, and the presence of cancer stem cells (CSCs) in HCC …
rate of heterogeneity and recurrence, and the presence of cancer stem cells (CSCs) in HCC …
Machine learning-assisted elucidation of CD81–CD44 interactions in promoting cancer stemness and extracellular vesicle integrity
Tumor-initiating cells with reprogramming plasticity or stem-progenitor cell properties
(stemness) are thought to be essential for cancer development and metastatic regeneration …
(stemness) are thought to be essential for cancer development and metastatic regeneration …
Cancer stem cells in hepatocellular carcinoma: intrinsic and extrinsic molecular mechanisms in stemness regulation
Hepatocellular carcinoma (HCC) remains the most predominant type of liver cancer with an
extremely poor prognosis due to its late diagnosis and high recurrence rate. One of the …
extremely poor prognosis due to its late diagnosis and high recurrence rate. One of the …
[HTML][HTML] Pancreatic cancer stem cell markers and exosomes-the incentive push
S Heiler, Z Wang, M Zöller - World journal of gastroenterology, 2016 - ncbi.nlm.nih.gov
Pancreatic cancer (PaCa) has the highest death rate and incidence is increasing. Poor
prognosis is due to late diagnosis and early metastatic spread, which is ascribed to a minor …
prognosis is due to late diagnosis and early metastatic spread, which is ascribed to a minor …
ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination
An inability to repair DNA double-strand breaks (DSBs) threatens genome integrity and can
contribute to human diseases, including cancer. Mammalian cells repair DSBs mainly …
contribute to human diseases, including cancer. Mammalian cells repair DSBs mainly …
Role of transmembrane 4 L six family 1 in the development and progression of cancer
F Fu, X Yang, M Zheng, Q Zhao, K Zhang… - Frontiers in molecular …, 2020 - frontiersin.org
Transmembrane 4 L six family 1 (TM4SF1) is a protein with four transmembrane domains
that belongs to the transmembrane 4 L six family members (TM4SFs). Structurally, TM4SF1 …
that belongs to the transmembrane 4 L six family members (TM4SFs). Structurally, TM4SF1 …