Autism is a complex, behaviorally defined, static disorder of the immature brain that is of
great concern to the practicing pediatrician because of an astonishing 556% reported …

Since autism was first recognized as a disorder in 1943, speculation about its aetiology has
ranged from biological to psychological and back again. After twin studies during the 1970s …

Twin and family studies in autistic disorders (AD) have elucidated a high heritability of the
narrow and broad phenotype of AD. In this review on the genetics of AD, we will initially …

Imbalanced levels of excitation and inhibition (E/I) have been proposed to account for
various behavioral and electrophysiological phenotypes in autism. Although proton …

The autism spectrum disorders (ASD) comprise a complex group of behaviorally related
disorders that are primarily genetic in origin. Involvement of epigenetic regulatory …

Autism is a common neurodevelopmental disorder with a significant genetic component.
Existing research suggests that multiple genes contribute to autism and that epigenetic …

The primary inhibitory and excitatory amino acid neurotransmitters are gamma-aminobutyric
acid (GABA) and glutamate, respectively. Despite their pervasiveness in brain function and …

A cluster of low copy repeats on the proximal long arm of chromosome 15 mediates various
forms of stereotyped deletions and duplication events that cause a group of …

The identification of the candidate genes for autism through linkage and association studies
has proven to be a difficult enterprise. An alternative approach is the analysis of cytogenetic …

The recent identification of decreased protein levels of glutamate decarboxylase (GAD) 65
and 67 isoforms in the autistic cerebellar tissue raises the possibility that abnormal …