Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound
Low-intensity ultrasound combined with intravenously injected microbubbles (US+ MB) is a
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …
Recent advances on ultrasound contrast agents for blood-brain barrier opening with focused ultrasound
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery.
Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to …
Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to …
A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease
G Leinenga, WK Koh, J Götz - Alzheimer's research & therapy, 2021 - Springer
Background Aducanumab is an anti-amyloid-β (Aβ) antibody that achieved reduced amyloid
pathology in Alzheimer's disease (AD) trials; however, it is controversial whether it also …
pathology in Alzheimer's disease (AD) trials; however, it is controversial whether it also …
Natural aging and Alzheimer's disease pathology increase susceptibility to focused ultrasound-induced blood–brain barrier opening
Focused Ultrasound (FUS) paired with systemically-injected microbubbles (μB) is capable of
transiently opening the blood–brain barrier (BBBO) for noninvasive and targeted drug …
transiently opening the blood–brain barrier (BBBO) for noninvasive and targeted drug …
Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound
Transport of interstitial fluid and solutes plays a critical role in clearing metabolic waste from
the brain. Transcranial application of focused ultrasound (FUS) has been shown to promote …
the brain. Transcranial application of focused ultrasound (FUS) has been shown to promote …
[HTML][HTML] A pilot clinical study of low-intensity transcranial focused ultrasound in Alzheimer's disease
Purpose Increasing attention has been paid to low-intensity transcranial focused ultrasound
(tFUS) for its potential therapeutic effects in Alzheimer's disease (AD). While preclinical …
(tFUS) for its potential therapeutic effects in Alzheimer's disease (AD). While preclinical …
Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model
Although blood-based liquid biopsy is a promising noninvasive technique to acquire a
comprehensive molecular tumor profile by detecting cancer-specific biomarkers (eg DNA …
comprehensive molecular tumor profile by detecting cancer-specific biomarkers (eg DNA …
[HTML][HTML] Multivariable-incorporating super-resolution residual network for transcranial focused ultrasound simulation
Background and objective: Transcranial focused ultrasound (tFUS) has emerged as a new
non-invasive brain stimulation (NIBS) modality, with its exquisite ability to reach deep brain …
non-invasive brain stimulation (NIBS) modality, with its exquisite ability to reach deep brain …
Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound
Efficient transport of solutes in the cerebrospinal fluid (CSF) plays a critical role in their
clearance from the brain. Convective bulk flow of solutes in the CSF in the perivascular …
clearance from the brain. Convective bulk flow of solutes in the CSF in the perivascular …
Ultrasound-mediated blood–brain barrier disruption for drug delivery: a systematic review of protocols, efficacy, and safety outcomes from preclinical and clinical …
Ultrasound-mediated blood–brain barrier (BBB) disruption has garnered focus as a method
of delivering normally impenetrable drugs into the brain. Numerous studies have …
of delivering normally impenetrable drugs into the brain. Numerous studies have …