Mechanistic modeling of semicontinuous fluidized bed drying of pharmaceutical granules by incorporating single particle and bulk drying kinetics
In this work, a mechanistic fluidized bed drying model computing the granule moisture
content in function of granule size, drying time, process settings and formulation properties is …
content in function of granule size, drying time, process settings and formulation properties is …
Validation of model-based design of experiments for continuous wet granulation and drying
K Matsunami, T Vandeputte, AAB Jiménez… - International Journal of …, 2023 - Elsevier
This paper presents an application case of model-based design of experiments for the
continuous twin-screw wet granulation and fluid-bed drying sequence. The proposed …
continuous twin-screw wet granulation and fluid-bed drying sequence. The proposed …
Cracking the code: Spatial heterogeneity as the missing piece for modeling granular fluidized bed drying
Pharmaceutical twin-screw wet granulation is a multifaceted and intricate process pivotal to
drug product development. Accurate modeling of this process is indispensable for optimizing …
drug product development. Accurate modeling of this process is indispensable for optimizing …