Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

The hemolytic–uremic syndrome, which is characterized by nonimmune hemolytic anemia,
thrombocytopenia, and renal impairment, occurs most frequently in young children. Most …

The autoinflammatory diseases are characterized by seemingly unprovoked episodes of
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …

Background Age-related macular degeneration is the most common cause of blindness in
Western populations. Susceptibility is influenced by age and by genetic and environmental …

Our understanding of the biology of the complement system has undergone a drastic
metamorphosis since its original discovery. This system, which was traditionally primarily …

The engineering of materials that can modulate the immune system is an emerging field that
is developing alongside immunology. For therapeutic ends such as vaccine development …

The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …

The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …

Platelets play an essential role in maintaining homeostasis in the circulatory system after an
injury by forming a platelet thrombus, but they also occupy a central node in the …

Atypical hemolytic uremic syndrome (aHUS) is a severe renal disease that is associated with
defective complement regulation caused by multiple factors. We previously described the …