Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering

S Eskandari, T Guerin, I Toth, RJ Stephenson - Advanced drug delivery …, 2017 - Elsevier
Self-assembled peptides have shown outstanding characteristics for vaccine delivery and
drug targeting. Peptide molecules can be rationally designed to self-assemble into specific …

Glycotherapy: new advances inspire a reemergence of glycans in medicine

JE Hudak, CR Bertozzi - Chemistry & biology, 2014 - cell.com
The beginning of the 20 th century marked the dawn of modern medicine with glycan-based
therapies at the forefront. However, glycans quickly became overshadowed as DNA-and …

Tumor-associated O-glycans of MUC1: Carriers of the glyco-code and targets for cancer vaccine design

DM Beckwith, M Cudic - Seminars in immunology, 2020 - Elsevier
The transformation from normal to malignant phenotype in human cancers is associated with
aberrant cell-surface glycosylation. It has frequently been reported that MUC1, the heavily …

The development of synthetic antitumour vaccines from mucin glycopeptide antigens

N Gaidzik, U Westerlind, H Kunz - Chemical Society Reviews, 2013 - pubs.rsc.org
Based on important cell-biological and biochemical results concerning the structural
difference between membrane glycoproteins of normal epithelial cells and epithelial tumour …

Supramolecular peptide nano-assemblies for cancer diagnosis and therapy: from molecular design to material synthesis and function-specific applications

Y Wang, X Zhang, K Wan, N Zhou, G Wei… - Journal of …, 2021 - Springer
Peptide molecule has high bioactivity, good biocompatibility, and excellent biodegradability.
In addition, it has adjustable amino acid structure and sequence, which can be flexible …

The influence of component structural arrangement on peptide vaccine immunogenicity

N Alharbi, M Skwarczynski, I Toth - Biotechnology Advances, 2022 - Elsevier
Peptide-based subunit vaccines utilise minimal immunogenic components (ie peptides) to
generate highly specific immune responses, without triggering adverse reactions. However …

Multivalent glyco (cyclo) peptides

MC Galan, P Dumy, O Renaudet - Chemical Society Reviews, 2013 - pubs.rsc.org
Because of the importance of carbohydrate–protein interactions in biological processes, the
development of glycoclusters and glycodendrimers capable of mimicking the multivalent …

Self‐adjuvanting synthetic antitumor vaccines from MUC1 glycopeptides conjugated to T‐cell epitopes from tetanus toxoid

H Cai, MS Chen, ZY Sun, YF Zhao… - Angewandte Chemie …, 2013 - Wiley Online Library
Tumor-associated MUC1 is considered a most promising target for the development of a
cancer immunotherapy. However, this endogenous glycoprotein expressed on many …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2009–2010

DJ Harvey - Mass spectrometry reviews, 2015 - Wiley Online Library
This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

TLR2 agonistic small molecules: detailed structure–activity relationship, applications, and future prospects

A Kaur, D Kaushik, S Piplani, SK Mehta… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are the pattern recognition receptors (PRRs) that recognize
pathogen-associated molecular patterns (PAMPs) in microbial species. Among the various …