[HTML][HTML] Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects
Abstract P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX)
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …
[HTML][HTML] Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications
Hydrogen sulfide (H 2 S) plays an important role in regulating various pathological
processes such as protecting mammalian cell from harmful injuries, promoting tissue …
processes such as protecting mammalian cell from harmful injuries, promoting tissue …
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
M Akman, DC Belisario, IC Salaroglio… - Journal of Experimental …, 2021 - Springer
Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …
condition, together with the aberrant activation of specific oncogenic patwhays, increases …
Recent advances in nanotechnology-based diagnosis and treatments of human osteosarcoma
Osteosarcoma (OSA) is a type of bone cancer that begins in the cells that form bones. OSA
is a rare mesenchymal bone neoplasm derived from mesenchymal stem cells. Genome …
is a rare mesenchymal bone neoplasm derived from mesenchymal stem cells. Genome …
Drug resistance in osteosarcoma: emerging biomarkers, therapeutic targets and treatment strategies
CM Hattinger, MP Patrizio, L Fantoni, C Casotti… - Cancers, 2021 - mdpi.com
Simple Summary Despite the adoption of aggressive, multimodal treatment schedules, the
cure rate of high-grade osteosarcoma (HGOS) has not significantly improved in the last 30 …
cure rate of high-grade osteosarcoma (HGOS) has not significantly improved in the last 30 …
Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response
The past few decades have witnessed significant progress in the discovery of hydrogen
sulfide (H 2 S) as a ubiquitous gaseous signaling molecule in mammalian physiology, akin …
sulfide (H 2 S) as a ubiquitous gaseous signaling molecule in mammalian physiology, akin …
[HTML][HTML] Nanomaterial-assisted theranosis of bone diseases
Bone-related diseases refer to a group of skeletal disorders that are characterized by bone
and cartilage destruction. Conventional approaches can regulate bone homeostasis to a …
and cartilage destruction. Conventional approaches can regulate bone homeostasis to a …
Engineering macromolecular nanocarriers for local delivery of gaseous signaling molecules
In addition to being notorious air pollutants, nitric oxide (NO), carbon monoxide (CO), and
hydrogen sulfide (H 2 S) have also been known as endogenous gaseous signaling …
hydrogen sulfide (H 2 S) have also been known as endogenous gaseous signaling …
On-demand therapeutic delivery of hydrogen sulfide aided by biomolecules
Y Ge, F Rong, W Li, Y Wang - Journal of Controlled Release, 2022 - Elsevier
Abstract Hydrogen sulfide (H 2 S), known as the third gasotransmitter, exerts various
physiological functions including cardiac protection, angiogenesis, anti-inflammatory, and …
physiological functions including cardiac protection, angiogenesis, anti-inflammatory, and …
An update on emerging drugs in osteosarcoma: towards tailored therapies?
CM Hattinger, MP Patrizio, F Magagnoli… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Current treatment of conventional and non-conventional high-grade
osteosarcoma (HGOS) is based on the surgical removal of primary tumor and, when …
osteosarcoma (HGOS) is based on the surgical removal of primary tumor and, when …