Mitochondria play an important role in numerous processes, including energy generation,
regulating ion homeostasis, and cell signaling. Mitochondria are also the main source of …

The role of altered redox status and high reactive oxygen species (ROS) is still controversial
in cancer development and progression. Intracellular levels of ROS are elevated in cancer …

Cancer cells maintain high levels of reactive oxygen species (ROS) to drive their growth, but
ROS can trigger cell death through oxidative stress and DNA damage. To survive enhanced …

To infect plants, pathogenic fungi secrete small proteins called effectors. Here, we describe
the catalytic activity and potential virulence function of the Nudix hydrolase effector AvrM14 …

Complex interactions in tumor microenvironment between ECM (extra-cellular matrix) and
cancer cell plays a central role in the generation of tumor supportive microenvironment. In …

Mammalian MutY homologue (MUTYH) is an adenine DNA glycosylase that excises
adenine inserted opposite 8-oxoguanine (8-oxoG). The inherited variations in human …

7, 8-Dihydro-8-oxoguanine (oxoG) is the most abundant oxidative DNA lesion with dual
coding properties. It forms both Watson–Crick (anti) oxoG:(anti) C and Hoogsteen (syn) …

In 2005 we reviewed microgravity for macromolecular crystallization, four years after the final
flight of the Space Shuttle Orbiter, and five years before the first commercial flight to the …

Escherichia coli MutT prevents mutations by hydrolyzing mutagenic 8-oxo-2'-
deoxyguanosine 5'-triphosphate (8-oxo-dGTP) in the presence of Mg2+ or Mn2+ ions. MutT …

Recent literature has both suggested and questioned MTH1 as a novel cancer target. BAY-
707 was just published as a target validation small molecule probe for assessing the effects …