Modern histologic imaging platforms coupled with machine learning methods have provided
new opportunities to map the spatial distribution of immune cells in the tumor …

Antibodies play a crucial role in basic research and clinical decision-making. However, there
are no standardized algorithms or guidelines to ensure their accuracy and validity. There …

Molecular subtype of breast cancer has defined the treatment direction of breast cancer and
guided the selection of drugs. Invasive tests such as tissue biopsy have the potential to …

Introduction Despite the clinical efficacy of immune checkpoint inhibitors (ICIs) in NSCLC,
only approximately 20% of patients remain disease-free at 5 years. Here, we use digital …

Background Breast cancer (BC) is the most common malignant tumor around the world.
Timely detection of the tumor progression after treatment could improve the survival outcome …

Simple Summary The evaluation of breast cancer immune microenvironment has been
increasingly used in clinical practice, either by counting tumor infiltrating lymphocytes or …

Pathology clinical practice has evolved by adopting technological advancements initially
regarded as potentially disruptive, such as electron microscopy, immunohistochemistry, and …

Introduction Survivin is an inhibitor of apoptosis that is proposed as a target for anti-cancer
therapy because of its high expression in cancer cells. It has potential as a prognostic and …

Spatial distribution of intra-tumoral immune cell populations is considered a critical
determinant of tumor evolution and response to therapy. The accurate and systemic search …

Emerging data indicate that genomic alterations can shape immune cell composition in early
breast cancer. However, there is a need for complementary imaging and sequencing …