Metformin as a first-line drug for type 2 diabetes mellitus (T2DM) treatment is widely studied.
Metformin can reduce liver glucose output and improve insulin resistance. Recent evidence …

Metformin, one of the first-line of hypoglycemic drugs, has cardioprotective, anti-
inflammatory and anticancer activities, in addition to its proven hypoglycemic effects …

Metformin is a first-line drug for treating type 2 diabetes mellitus (T2DM) and one of the most
commonly prescribed drugs in the world. Besides its hypoglycemic effects, metformin also …

Alzheimer's disease (AD) is a prevalent neurodegenerative disease predominantly affecting
millions of elderly people. To date, no effective therapy has been identified to reverse the …

Alzheimer's disease (AD) is one of the most devastating brain disorders. Currently, there are
no effective treatments to stop the disease progression and it is becoming a major public …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which results in
dementia typically in the elderly. The disease is mainly characterized by the deposition of …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, also regarded as
“type 3 diabetes” for the last few years because of the brain insulin resistance (IR) and …

Metformin, a widely prescribed medication for type 2 diabetes, has garnered increasing
attention for its potential neuroprotective properties due to the growing demand for …

Metformin has been used for the treatment of type II diabetes mellitus for decades due to its
safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying …

Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in
the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of …