Introduction: A large proportion of prescribed drugs to children are administered orally. Age-
related change in factors affecting oral absorption can have consequences for drug dosing …

We review the current clinical evaluation and management of the most common esophageal
and gastrointestinal motility disorders in children based on the literature and our experience …

OBJECTIVES: Children with surgically repaired Hirschsprung's disease (HD) and those with
internal anal sphincter (IAS) achalasia may develop obstructive gastrointestinal symptoms …

BACKGROUND/PURPOSE: Recently, the transanal 1-stage pull-through operation has
been widely used in Hirschsprung disease (HD), and it is obviously superior to traditional …

Purpose Chronic obstructive defecation can occur in patients with Hirschsprung Disease
(HD) and internal anal sphincter (IAS) achalasia. Injection of Botulinum Toxin (BoTox) into …

Gastrointestinal motor dysfunction persists in a large number of children subjected to
surgical treatment for Hirschsprung's disease, indicating abnormalities in the remaining …

Hirschsprung's disease (HD) is a relatively common cause of intestinal obstruction in the
newborn. It is characterized by absence of ganglionic cells in the distal bowel beginning at …

Background: Little is known about anorectal function in patients after surgery for
Hirschsprung's disease. Therefore, the authors evaluated anorectal sphincter function after …

Abnormalities in the development of enteric neural crest-derived progenitors (ENPs) that
generate the enteric nervous system (ENS) can lead to aganglionosis in a variable portion of …

Historically, gastroparesis is characterized by delayed gastric emptying of fluids and/or
solids without evidence of a mechanical gastric outlet obstruction. To provide a thorough …