[HTML][HTML] Corneal endothelial dysfunction: Evolving understanding and treatment options

MO Price, JS Mehta, UV Jurkunas… - Progress in retinal and eye …, 2021 - Elsevier
The cornea is exquisitely designed to protect the eye while transmitting and focusing
incoming light. Precise control of corneal hydration by the endothelial cell layer that lines the …

[HTML][HTML] Approaches for corneal endothelium regenerative medicine

P Catala, G Thuret, H Skottman, JS Mehta… - Progress in retinal and …, 2022 - Elsevier
The state of the art therapy for treating corneal endothelial disease is transplantation.
Advances in the reproducibility and accessibility of surgical techniques are increasing the …

[HTML][HTML] Gene therapy in the anterior eye segment

C Amador, R Shah, S Ghiam, AA Kramerov… - Current gene …, 2022 - ncbi.nlm.nih.gov
This review provides comprehensive information about the advances in gene therapy in the
anterior segment of the eye, including cornea, conjunctiva, lacrimal gland, and trabecular …

Efficient generation of human embryonic stem cell-derived corneal endothelial cells by directed differentiation

KL McCabe, NJ Kunzevitzky, BP Chiswell, X Xia… - PLoS …, 2015 - journals.plos.org
Aim To generate human embryonic stem cell derived corneal endothelial cells (hESC-
CECs) for transplantation in patients with corneal endothelial dystrophies. Materials and …

Substrates for expansion of corneal endothelial cells towards bioengineering of human corneal endothelium

J Navaratnam, TP Utheim, VK Rajasekhar… - Journal of functional …, 2015 - mdpi.com
Corneal endothelium is a single layer of specialized cells that lines the posterior surface of
cornea and maintains corneal hydration and corneal transparency essential for vision …

Regeneration of the corneal endothelium

N Okumura, N Koizumi - Current eye research, 2020 - Taylor & Francis
Penetrating keratoplasty was the only therapeutic choice for the treatment of corneal
endothelial decompensation until the introduction of evolutional endothelial keratoplasties …

Corneal endothelium tissue engineering: An evolution of signaling molecules, cells, and scaffolds toward 3D bioprinting and cell sheets

M Khalili, M Asadi, H Kahroba… - Journal of Cellular …, 2021 - Wiley Online Library
Cornea is an avascular and transparent tissue that focuses light on retina. Cornea is
supported by the corneal‐endothelial layer through regulation of hydration homeostasis …

Increasing the Efficacy of Stem Cell Therapy via Triple-Function Inorganic Nanoparticles

F Chen, ER Zhao, G Hableel, T Hu, T Kim, J Li… - ACS …, 2019 - ACS Publications
Stem cell therapy in heart disease is challenged by mis-injection, poor survival, and low cell
retention. Here, we describe a biocompatible multifunctional silica–iron oxide nanoparticle …

Interaction of nanoparticles with blood components and associated pathophysiological effects

GG De La Cruz, P Rodríguez-Fragoso… - Unraveling the safety …, 2018 - books.google.com
Nanotechnology currently plays a pivotal role in several fields and has enabled substantial
advances in a relatively short time. In biomedicine, nanomaterials can be potentially …

Safety and toxicity of nanomaterials for ocular drug delivery applications

NK Mehra, D Cai, L Kuo, T Hein, S Palakurthi - Nanotoxicology, 2016 - Taylor & Francis
Multifunctional nanomaterials are rapidly emerging for ophthalmic delivery of therapeutics to
facilitate safe and effective targeting with improved patient compliance. Because of their …