The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

The recognition of modified histones by" reader" proteins constitutes a key mechanism
regulating gene expression in the chromatin context. Compared with the great variety of …

The packaging of chromosomal DNA by nucleosomes condenses and organizes the
genome, but occludes many regulatory DNA elements. However, this constraint also allows …

Recent exon sequencing studies have revealed that over 20% of human tumors have
mutations in subunits of mSWI/SNF (BAF) complexes. To investigate the underlying …

Plants are highly sensitive to temperature and can perceive a difference of as little as 1° C.
How temperature is sensed and integrated in development is unknown. In a forward genetic …

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …

Knowing the precise locations of nucleosomes in a genome is key to understanding how
genes are regulated. Recent'next generation'ChIP–chip and ChIP–Seq technologies have …

The positioning of nucleosomes with respect to DNA plays an important role in regulating
transcription. However, nucleosome mapping has been performed for only limited genomic …

Precise gene expression ensures proper stem and progenitor cell differentiation, lineage
commitment and organogenesis during mammalian development. ATP-dependent …