[HTML][HTML] Интерстициальные заболевания легких при ревматоидном артрите: мультидисциплинарная проблема ревматологии и пульмонологии

ЕЛ Насонов, ЛП Ананьева… - Научно-практическая …, 2022 - cyberleninka.ru
Ревматоидный артрит (РА)-иммуновоспалительное ревматическое заболевание
(ИВРЗ), характеризующееся хроническим эрозивным артритом и системным …

Highlights of strategies targeting fibroblasts for novel therapies for rheumatoid arthritis

CQ Chu - Frontiers in Medicine, 2022 - frontiersin.org
Synovial fibroblasts of rheumatoid arthritis (RA) play a critical role in perpetuation of chronic
inflammation by interaction with immune and inflammatory cells and in cartilage and bone …

Network pharmacology and molecular docking study of the Chinese miao medicine sidaxue in the treatment of rheumatoid arthritis

N Wu, T Yuan, ZX Yin, X Yuan, J Sun, Z Wu… - Drug Design …, 2023 - Taylor & Francis
Purpose This study aimed to investigate the molecular mechanisms of Compound Sidaxue
(SX), a prescription of Chinese Miao medicine, in treating rheumatoid arthritis (RA) using …

[HTML][HTML] Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling …

Q Tang, C Xing, M Li, Q Jia, C Bo, Z Zhang - … and environmental safety, 2022 - Elsevier
Macrophages play an important role in causing silicosis eventually becoming an irreversible
fibrotic disease, and there are no specific drugs for silicosis in the clinic so far. Pirfenidone …

Microwave hyperthermia-responsible flexible liposomal gel as a novel transdermal delivery of methotrexate for enhanced rheumatoid arthritis therapy

Q Shen, T Tang, Q Hu, X Ying, G Shu, C Teng… - Biomaterials …, 2021 - pubs.rsc.org
Methotrexate (MTX) as an anti-inflammatory drug for the treatment of rheumatoid arthritis
(RA) through oral and injectable administration is still problematic in the clinic. Herein, a …

Polyester Nanoparticles and Polyurethane Nanocapsules Deliver Pirfenidone To Reduce Fibrosis and Scarring

S Liu, T Ale, V Kehinde, T Ale, HC Wang… - … Biomaterials Science & …, 2023 - ACS Publications
Pirfenidone has been shown to reduce fibrosis and modulate inflammation associated with
conditions from pulmonary fibrosis to rheumatoid arthritis. It may also be useful for ocular …

Ra Fibroblast-like synoviocytes derived extracellular vesicles promote angiogenesis by mirna-1972 targeting P53/Mtor signaling in vascular endotheliocyte

Y Chen, J Dang, X Lin, M Wang, Y Liu, J Chen… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory
in joints. Invasive pannus is a characteristic pathological feature of RA. RA fibroblast-like …

Isolation and identification of the components in Cybister chinensis Motschulsky against inflammation and their mechanisms of action based on network pharmacology …

YH Che, ZR Xu, LL Ni, XX Dong, ZZ Yang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Cybister chinensis Motschulsky belongs to the family
Dytiscidae. As a traditional Chinese medicine, the insect is called Longshi in the folk and is …

An AI Approach to Identifying Novel Therapeutics for Rheumatoid Arthritis

JR Rajan, S McDonald, AJ Bjourson, SD Zhang… - Journal of Personalized …, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that has a significant impact on
quality of life and work capacity. Treatment of RA aims to control inflammation and alleviate …

[HTML][HTML] Intra-articular sustained-release of pirfenidone as a disease-modifying treatment for early osteoarthritis

X Zhu, M Cao, K Li, YT Chan, HF Chan, YW Mak… - Bioactive Materials, 2024 - Elsevier
Osteoarthritis (OA) is a major clinical challenge, and effective disease-modifying drugs for
OA are still lacking due to the complicated pathology and scattered treatment targets …