Combined diffusion‐relaxometry microstructure imaging: Current status and future prospects

PJ Slator, M Palombo, KL Miller… - Magnetic resonance …, 2021 - Wiley Online Library
Microstructure imaging seeks to noninvasively measure and map microscopic tissue
features by pairing mathematical modeling with tailored MRI protocols. This article reviews …

Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI

DK Jones, DC Alexander, R Bowtell, M Cercignani… - NeuroImage, 2018 - Elsevier
The key component of a microstructural diffusion MRI 'super-scanner'is a dedicated high-
strength gradient system that enables stronger diffusion weightings per unit time compared …

TE dependent Diffusion Imaging (TEdDI) distinguishes between compartmental T2 relaxation times

J Veraart, DS Novikov, E Fieremans - NeuroImage, 2018 - Elsevier
Biophysical modeling of macroscopic diffusion-weighted MRI signal in terms of microscopic
cellular parameters holds the promise of quantifying the integrity of white matter …

Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brain

D Benjamini, D Iacono, ME Komlosh, DP Perl… - Brain, 2021 - academic.oup.com
Axonal injury is a major contributor to the clinical symptomatology in patients with traumatic
brain injury. Conventional neuroradiological tools, such as CT and MRI, are insensitive to …

Towards unconstrained compartment modeling in white matter using diffusion‐relaxation MRI with tensor‐valued diffusion encoding

B Lampinen, F Szczepankiewicz… - Magnetic resonance …, 2020 - Wiley Online Library
Purpose To optimize diffusion‐relaxation MRI with tensor‐valued diffusion encoding for
precise estimation of compartment‐specific fractions, diffusivities, and T2 values within a two …

Diffusion‐relaxation correlation spectroscopic imaging: a multidimensional approach for probing microstructure

D Kim, EK Doyle, JL Wisnowski… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose To propose and evaluate a novel multidimensional approach for imaging subvoxel
tissue compartments called Diffusion‐Relaxation Correlation Spectroscopic Imaging. Theory …

[HTML][HTML] Probing brain tissue microstructure with MRI: principles, challenges, and the role of multidimensional diffusion-relaxation encoding

B Lampinen, F Szczepankiewicz, J Lätt, L Knutsson… - NeuroImage, 2023 - Elsevier
Diffusion MRI uses the random displacement of water molecules to sensitize the signal to
brain microstructure and to properties such as the density and shape of cells. Microstructure …

Mapping astrogliosis in the individual human brain using multidimensional MRI

D Benjamini, DS Priemer, DP Perl, DL Brody… - Brain, 2023 - academic.oup.com
There are currently no non-invasive imaging methods available for astrogliosis assessment
or mapping in the central nervous system despite its essential role in the response to many …

C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter

MH Alsameen, Z Gong, W Qian, M Kiely… - Frontiers in …, 2023 - frontiersin.org
Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of
neurite density and dispersion through computation of the neurite density index (NDI) and …

Computing and visualising intra‐voxel orientation‐specific relaxation–diffusion features in the human brain

JP de Almeida Martins, CMW Tax… - Human brain …, 2021 - Wiley Online Library
Diffusion MRI techniques are used widely to study the characteristics of the human brain
connectome in vivo. However, to resolve and characterise white matter (WM) fibres in …