Structural basis for regulation of phosphoinositide kinases and their involvement in human disease
JE Burke - Molecular cell, 2018 - cell.com
Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …
The membrane surface as a platform that organizes cellular and biochemical processes
Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …
and organelles. In addition, their surfaces actively participate in biochemical reaction …
Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease
MK Rathinaswamy, JE Burke - Advances in Biological Regulation, 2020 - Elsevier
The Class I phosphoinositide 3-kinases (PI3Ks) are a group of heterodimeric lipid kinases
that regulate crucial cellular processes including proliferation, survival, growth, and …
that regulate crucial cellular processes including proliferation, survival, growth, and …
The importance of being PI3K in the RAS signaling network
C Cuesta, C Arévalo-Alameda, E Castellano - Genes, 2021 - mdpi.com
Ras proteins are essential mediators of a multitude of cellular processes, and its
deregulation is frequently associated with cancer appearance, progression, and metastasis …
deregulation is frequently associated with cancer appearance, progression, and metastasis …
[HTML][HTML] Insulin-driven PI3K-AKT signaling in the hepatocyte is mediated by redundant PI3Kα and PI3Kβ activities and is promoted by RAS
Summary Phosphatidylinositol-3-kinase (PI3K) activity is aberrant in tumors, and PI3K
inhibitors are investigated as cancer therapeutics. PI3K signaling mediates insulin action in …
inhibitors are investigated as cancer therapeutics. PI3K signaling mediates insulin action in …
Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that perform multiple and
important cellular functions. The protein investigated here belongs to class IA of the PI3Ks; it …
important cellular functions. The protein investigated here belongs to class IA of the PI3Ks; it …
Molecular mechanisms of human disease mediated by oncogenic and primary immunodeficiency mutations in class IA phosphoinositide 3-kinases
GL Dornan, JE Burke - Frontiers in immunology, 2018 - frontiersin.org
The signaling lipid phosphatidylinositol 3, 4, 5, trisphosphate (PIP3) is an essential mediator
of many vital cellular processes, including growth, survival, and metabolism. PIP3 is …
of many vital cellular processes, including growth, survival, and metabolism. PIP3 is …
[HTML][HTML] Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes
The lipid kinase VPS34 orchestrates diverse processes, including autophagy, endocytic
sorting, phagocytosis, anabolic responses and cell division. VPS34 forms various …
sorting, phagocytosis, anabolic responses and cell division. VPS34 forms various …
Spatial organization of PI3K-PI (3, 4, 5) P3-AKT signaling by focal adhesions
J Wang, Z An, Z Wu, W Zhou, P Sun, P Wu, S Dang… - Molecular Cell, 2024 - cell.com
The class I phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is a key regulator of
cell survival, growth, and proliferation and is among the most frequently mutated pathways in …
cell survival, growth, and proliferation and is among the most frequently mutated pathways in …
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus
ML Jenkins, H Ranga-Prasad, MAH Parson… - Nature …, 2023 - nature.com
PIK3CA encoding the phosphoinositide 3-kinase (PI3K) p110α catalytic subunit is frequently
mutated in cancer, with mutations occurring widely throughout the primary sequence. The …
mutated in cancer, with mutations occurring widely throughout the primary sequence. The …