Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Conspectus Metal ions have been identified as key factors modulating the aggregation of
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …

Abstract 2012 has been another year in which multiple large-scale clinical trials for
Alzheimer's disease (AD) have failed to meet their clinical endpoints. With the social and …

Neurodegenerative diseases are among the most challenging diseases with poorly known
mechanism of cause and paucity of complete cure. Out of all the neurodegenerative …

The chemistry of Alzheimer’s disease - Chemical Society Reviews (RSC Publishing) DOI:10.1039/B807980N
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B807980N …

Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …

Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

Alzheimer's disease (AD) is a complex age‐related neurodegenerative disease. In this
review, we carefully detail amyloid‐β metabolism and its role in AD. We also consider the …