Polyketides represent an important class of natural products, renowned for their intricate
structures and diverse biological activities. In contrast to common fatty acids, polyketides …

Oxygen plays a crucial role in the metabolic processes of non-anaerobic organisms.
However, a detailed understanding of how triplet oxygen participates in the enzymatic …

Angucyclines are type II polyketide natural products, often characterized by unusual
structural rearrangements through B-or C-ring cleavage of their tetracyclic backbone. While …

Flavoenzymes can mediate a large variety of oxidation reactions through the activation of
oxygen. However, the O2 activation chemistry of flavin enzymes is not yet fully exploited …

Background Malaria is a major global health concern, particularly in tropical and subtropical
countries. With growing resistance to first-line treatment with artemisinin, there is an urgent …

An atypical nonheme iron-dependent dioxygenase BTG13 with a rare iron coordination of
four histidine residues and a carboxylated-lysine (Kcx) was recently reported to catalyze the …

Oxygenases are important biocatalysts to produce many industrially important biomolecules.
Here, a novel oxygenase, named MoxA, was identified through screening of a deep-sea …

Oxepinone rings represent one of structurally unusual motifs of natural products and the
biosynthesis of oxepinones is not fully understood. 1, 5-Seco-vibralactone (3) features an …

Flavin-dependent catalysts are widely applied to aerobic monooxygenation/oxidation
reactions. In contrast, flavin-catalyzed aerobic dioxygenation reactions exhibit higher atomic …

Mangrove derived actinomycetes are a rich reservoir of bioactive natural products and play
important roles in pharmaceutical chemistry. In a screen of actinomycetes from mangrove …