On Earth, humans are subjected to a gravitational force that has been an important
determinant in human evolution and function. During spaceflight, astronauts are subjected to …

Spaceflight and its associated stressors, such as microgravity, radiation exposure,
confinement, circadian derailment and disruptive workloads represent an unprecedented …

The endothelial cells (ECs), which line the inner surface of vessels, play a fundamental role
in maintaining vascular integrity and tissue homeostasis, since they regulate local blood flow …

Wound healing is a complex phenomenon that involves different cell types with various
functions, ie, keratinocytes, fibroblasts, and endothelial cells, all influenced by the action of …

Exposure to microgravity results in vascular remodeling and cardiovascular dysfunction. To
elucidate the mechanism involved in this condition, we investigated whether endoplasmic …

The study of the effects of ionizing radiation on organisms is related to different research
aims. The current review emphasizes the studies on the effects of different doses of sparsely …

Medications have been used during space missions for more than half a century, yet our
understanding of the effects of spaceflight on drug pharmacokinetics and …

Decades of spaceflight studies have provided abundant evidence that individual cells in
vitro are capable of sensing space microgravity and responding with cellular changes both …

As human spaceflight progresses with extended mission durations, the demand for effective
and safe drugs will necessarily increase. To date, the accepted medications used during …

Purpose: Inhibition of growth in mammalian cells in response to damage or stress is known
as cellular senescence. Increasing evidence suggests that double-strand breaks (DSB) …