Transcriptional pausing as a mediator of bacterial gene regulation
R Landick - Annual Review of Microbiology, 2021 - annualreviews.org
Cellular life depends on transcription of DNA by RNA polymerase to express genetic
information. RNA polymerase has evolved not just to read information from DNA and write it …
information. RNA polymerase has evolved not just to read information from DNA and write it …
A roadmap for rRNA folding and assembly during transcription
ML Rodgers, SA Woodson - Trends in biochemical sciences, 2021 - cell.com
Ribonucleoprotein (RNP) assembly typically begins during transcription when folding of the
newly synthesized RNA is coupled with the recruitment of RNA-binding proteins (RBPs) …
newly synthesized RNA is coupled with the recruitment of RNA-binding proteins (RBPs) …
Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ
N Said, T Hilal, ND Sunday, A Khatri, J Bürger, T Mielke… - Science, 2021 - science.org
INTRODUCTION Factor-dependent transcription termination is essential to limit pervasive
transcription, maintain genome stability, balance the expression of neighboring genes, and …
transcription, maintain genome stability, balance the expression of neighboring genes, and …
Concerted transformation of a hyper-paused transcription complex and its reinforcing protein
RfaH, a paralog of the universally conserved NusG, binds to RNA polymerases (RNAP) and
ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical …
ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical …
Near-physiological in vitro assembly of 50S ribosomes involves parallel pathways
Understanding the assembly principles of biological macromolecular complexes remains a
significant challenge, due to the complexity of the systems and the difficulties in developing …
significant challenge, due to the complexity of the systems and the difficulties in developing …
NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA
NusA and NusG are transcription factors that stimulate RNA polymerase pausing in Bacillus
subtilis. While NusA was known to function as an intrinsic termination factor in B. subtilis, the …
subtilis. While NusA was known to function as an intrinsic termination factor in B. subtilis, the …
Sm-like protein Rof inhibits transcription termination factor ρ by binding site obstruction and conformational insulation
Transcription termination factor ρ is a hexameric, RNA-dependent NTPase that can adopt
active closed-ring and inactive open-ring conformations. The Sm-like protein Rof, a homolog …
active closed-ring and inactive open-ring conformations. The Sm-like protein Rof, a homolog …
NusG, an ancient yet rapidly evolving transcription factor
B Wang, I Artsimovitch - Frontiers in Microbiology, 2021 - frontiersin.org
Timely and accurate RNA synthesis depends on accessory proteins that instruct RNA
polymerase (RNAP) where and when to start and stop transcription. Among thousands of …
polymerase (RNAP) where and when to start and stop transcription. Among thousands of …
Dynamic competition between a ligand and transcription factor NusA governs riboswitch-mediated transcription regulation
Cotranscriptional RNA folding is widely assumed to influence the timely control of gene
expression, but our understanding remains limited. In bacteria, the fluoride (F−)-sensing …
expression, but our understanding remains limited. In bacteria, the fluoride (F−)-sensing …
Tracking transcription–translation coupling in real time
NS Qureshi, O Duss - Nature, 2025 - nature.com
A central question in biology is how macromolecular machines function cooperatively. In
bacteria, transcription and translation occur in the same cellular compartment, and can be …
bacteria, transcription and translation occur in the same cellular compartment, and can be …