The molecular biology of head and neck cancer

CR Leemans, BJM Braakhuis, RH Brakenhoff - Nature reviews cancer, 2011 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are caused by tobacco and alcohol
consumption and by infection with high-risk types of human papillomavirus (HPV). Tumours …

[HTML][HTML] Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach

JA Langendijk, P Lambin, D De Ruysscher… - Radiotherapy and …, 2013 - Elsevier
Most new radiation techniques, have been introduced primarily to reduce the dose to normal
tissues in order to prevent radiation-induced side effects. Radiotherapy with protons is such …

Prevention and treatment of radiotherapy‐induced side effects

L Barazzuol, RP Coppes, P van Luijk - Molecular oncology, 2020 - Wiley Online Library
Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of
patients. The precision with which the radiation dose can be delivered is rapidly improving …

Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial

CM Nutting, JP Morden, KJ Harrington… - The lancet …, 2011 - thelancet.com
Background Xerostomia is the most common late side-effect of radiotherapy to the head and
neck. Compared with conventional radiotherapy, intensity-modulated radiotherapy (IMRT) …

The prevalence and risk factors associated with osteoradionecrosis of the jaw in oral and oropharyngeal cancer patients treated with intensity-modulated radiation …

AA Owosho, CJ Tsai, RS Lee, H Freymiller… - Oral oncology, 2017 - Elsevier
Objective To determine the prevalence and correlation of various risk factors [radiation dose,
periodontal status, alcohol and smoking] to the development of osteoradionecrosis (ORN) …

Head and neck cancers, version 2.2014

DG Pfister, S Spencer, DM Brizel, B Burtness… - Journal of the National …, 2014 - jnccn.org
This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)
for Head and Neck Cancers focuses on glottic laryngeal cancer, which is the most common …

Intensity-modulated radiation therapy for head and neck cancer: systematic review and meta-analysis

GN Marta, V Silva, H de Andrade Carvalho… - Radiotherapy and …, 2014 - Elsevier
Background and purpose Intensity-modulated radiation therapy (IMRT) provides the
possibility of dose-escalation with better normal tissue sparing. This study was performed to …

Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers

A Vissink, JB Mitchell, BJ Baum, KH Limesand… - International Journal of …, 2010 - Elsevier
The most significant long-term complication of radiotherapy in the head-and-neck region is
hyposalivation and its related complaints, particularily xerostomia. This review addresses …

The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex

L Verduci, M Ferraiuolo, A Sacconi, F Ganci, J Vitale… - Genome biology, 2017 - Springer
Abstract Background Circular RNAs are a class of endogenous RNAs with various functions
in eukaryotic cells. Worthy of note, circular RNAs play a critical role in cancer. Currently …

[HTML][HTML] Predictive modelling for swallowing dysfunction after primary (chemo) radiation: results of a prospective observational study

MEMC Christianen, C Schilstra, I Beetz… - Radiotherapy and …, 2012 - Elsevier
BACKGROUND AND PURPOSE: The purpose of this large multicentre prospective cohort
study was to identify which dose volume histogram parameters and pre-treatment factors are …