Human inborn errors of immunity: an expanding universe
Molecular, cellular, and clinical studies of human inborn errors of immunity have
revolutionized our understanding of their pathogenesis, considerably broadened their …
revolutionized our understanding of their pathogenesis, considerably broadened their …
Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases
N Ohkura, S Sakaguchi - Cell research, 2020 - nature.com
Naturally arising regulatory CD4+ T (Treg) cells, which specifically express the transcription
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …
immunology and flow cytometry community. They provide the theory and key practical …
Inflammation–nature's way to efficiently respond to all types of challenges: implications for understanding and managing “the epidemic” of chronic diseases
Siloed or singular system approach to disease management is common practice,
developing out of traditional medical school education. Textbooks of medicine describe a …
developing out of traditional medical school education. Textbooks of medicine describe a …
Regulatory T cells: the many faces of Foxp3
Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …
requisite role in the maintenance of immunological homeostasis and prevention of …
T cell responses: naive to memory and everything in between
ND Pennock, JT White, EW Cross… - Advances in …, 2013 - journals.physiology.org
THE MAMMALIAN IMMUNE SYSTEM can be broadly divided into two main arms: innate and
adaptive immunity. As its name implies, the cells and receptors of the innate immune system …
adaptive immunity. As its name implies, the cells and receptors of the innate immune system …
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
JA Bluestone, JH Buckner, M Fitch… - Science translational …, 2015 - science.org
Type 1 diabetes (T1D) is an autoimmune disease that occurs in genetically susceptible
individuals. Regulatory T cells (Tregs) have been shown to be defective in the autoimmune …
individuals. Regulatory T cells (Tregs) have been shown to be defective in the autoimmune …
From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation
R Bacchetta, F Barzaghi… - Annals of the New York …, 2018 - Wiley Online Library
Immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome is a
rare disorder that increasingly has gained attention as a model of genetic autoimmunity …
rare disorder that increasingly has gained attention as a model of genetic autoimmunity …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …
performing flow cytometry experiments and includes comprehensive sections describing …
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
N Ohkura, M Hamaguchi, H Morikawa, K Sugimura… - Immunity, 2012 - cell.com
The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells,
yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that …
yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that …