Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

The management of patients with migraine is often unsatisfactory because available acute
and preventive therapies are either ineffective or poorly tolerated. The acute treatment of …

Migraine is a complex disorder of the brain whose mechanisms are only now being
unraveled. It is common, disabling and economically costly. The pain suggests an important …

Migraine is a common, disabling disorder of the central nervous system. The disorder has
three key features. The tendency is largely inherited, the sufferer is sensitive to exogenous …

Background: The development of new agents for the preventive treatment of migraine is the
greatest unmet need in the therapeutics of primary headaches. Topiramate, an …

Primary headache disorders represent a remarkable opportunity for clinical neuroscience to
improve patients' lives in substantial numbers and reduce societal economic burden (Olesen …

Chronic migraine (CM) is a common and disabling disorder that remains underdiagnosed
and poorly treated. Significant unmet therapeutic needs add to the burden of this disorder; …

Background: Migraine is a common and disabling neurological disorder. Although the
pharmacotherapy of migraine has advanced in parallel with our understanding of the …

In recent years bench-based studies have greatly enhanced our understanding of headache
pathophysiology, while facilitating the development of new headache medicines. At present …

Migraine is a neurovascular disorder that is associated with severe headache and
neurologic symptoms. The pathogenesis of migraine is believed to involve …