Appearance of pathogenic bacteria resistant to most, if not all, known antibiotics is currently
one of the most significant medical problems. Therefore, development of novel antibacterial …

Studies over more than half a century have resulted in what some consider a complete
narrative for the life cycle of bacteriophage λ. However, this narrative is only complete within …

In the noisy cellular environment, gene products are subject to inherent random fluctuations
in copy numbers over time. How cells ensure precision in the timing of key intracellular …

Viruses are differentiated from other mobile genetic elements by the encapsidation of their
genomes during some stage of their life cycles. It is during their infection of bacteria that …

Stochastic protein accumulation up to some concentration threshold sets the timing of many
cellular physiological processes. Here we obtain the exact distribution of first threshold …

Bacterial communities are often exposed to temporal variations in resource availability,
which exceed bacterial generation times and thereby affect bacterial coexistence. Bacterial …

The inherent stochastic nature of biochemical processes can drive differences in gene
expression between otherwise identical cells. While cell-to-cell variability in gene …

How the noisy expression of regulatory proteins affects timing of intracellular events is an
intriguing fundamental problem that influences diverse cellular processes. Here we use the …

Quantifying viral traits—including the adsorption rate, burst size, and latent period—is critical
to characterize viral infection dynamics and develop predictive models of viral impacts …

A major challenge in evolutionary biology is explaining how populations navigate rugged
fitness landscapes without getting trapped on local optima. One idea illustrated by adaptive …