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The period 2000–2015 brought the advent of high-throughput approaches to protein
structure determination. With the overall funding on the order of $2 billion (in 2010 dollars) …

Motivation: Individual research groups now analyze thousands of samples per year at
synchrotron macromolecular crystallography (MX) resources. The efficient management of …

Crystallization remains the bottleneck in the crystallographic process leading from a gene to
a three-dimensional model of the encoded protein or RNA. Automation of the individual …

Modern high-throughput structural biology laboratories produce vast amounts of raw
experimental data. The traditional method of data reduction is very simple—results are …

A broad working definition of structural proteomics (SP) is that it is the process of the high-
throughput characterization of the three-dimensional structures of biological …

Background Life-science laboratories make increasing use of Next Generation Sequencing
(NGS) for studying bio-macromolecules and their interactions. Array-based methods for …

The advance of new technologies in biomedical research has led to a dramatic growth in
experimental throughput. Projects therefore steadily grow in size and involve a larger …

The Pi sampling method is derived from the incomplete factorial approach to
macromolecular crystallization screen design. The resultingPi screens' have a modular …

Modern synchrotron beamlines offer instrumentation of unprecedented quality, which in turn
encourages increasingly marginal experiments, and for these, as much as ever, the ultimate …