The process of ageing is characteristic of multicellular organisms associated with late stages
of the lifecycle and is manifested through a plethora of phenotypes. Its underlying …

DNA methylation is one of the epigenetic modifications of the genome, the essence of which
is the attachment of a methyl group to nitrogenous bases. In the eukaryote genome, cytosine …

Parkinson's disease (PD) is the neurological disorder showing the greatest rise in
prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to …

Abstract Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for
α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but …

Advanced age represents one of the major risk factors for Parkinson's Disease. Recent
biomedical studies posit a role for microRNAs, also known to be remodelled during ageing …

Employee attrition is a major problem that causes many companies to incur in significant
costs to find and hire new personnel. The use of machine learning and artificial intelligence …

Neuroinflammation is a core feature of Parkinson disease (PD) and related disorders.
Inflammation is detectable early in PD and persists throughout the disease state. Both the …

The automotive market is experiencing, in recent years, a period of deep transformation.
Increasingly stricter rules on pollutant emissions and greater awareness of air quality by …

While there is sustained growth of the older population worldwide, ageing is a consistent risk
factor for neurodegenerative diseases, such as Parkinson's-disease (PD). Considered an …

With the increasing age of the population, the incidence of Parkinson's disease (PD) has
increased exponentially. The development of novel therapeutic interventions requires an …