Alpha‐1‐antitrypsin: a possible host protective factor against Covid‐19

MB de Loyola, TTA Dos Reis… - Reviews in medical …, 2021 - Wiley Online Library
Understanding Covid‐19 pathophysiology is crucial for a better understanding of the
disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a …

Augmentation therapy in alpha-1 antitrypsin deficiency: advances and controversies

AR Tonelli, ML Brantly - Therapeutic advances in respiratory …, 2010 - journals.sagepub.com
Alpha-1 antitrypsin (AAT) deficiency is a hereditary condition characterized by low levels of
AAT in plasma and hence diffusion into tissues. One of the most relevant characteristics of …

New Findings in PiZZ α1-Antitrypsin Deficiency-Related PanniculitisDemonstration of Skin Polymers and High Dosing Requirements of Intravenous Augmentation …

B Gross, M Grebe, M Wencker, JK Stoller, LM Bjursten… - Dermatology, 2009 - karger.com
Panniculitis is a recognized but unusual complication of a severe deficiency of α 1-
antitrypsin (AAT), with fewer than 100 cases described to date. Like the pathogenesis of …

Prolastin, a pharmaceutical preparation of purified human α1-antitrypsin, blocks endotoxin-mediated cytokine release

I Nita, C Hollander, U Westin, SM Janciauskiene - Respiratory research, 2005 - Springer
Abstract Background α1-antitrypsin (AAT) serves primarily as an inhibitor of the elastin
degrading proteases, neutrophil elastase and proteinase 3. There is ample clinical evidence …

Diagnóstico y tratamiento del déficit de alfa-1-antitripsina

R Vidal, I Blanco, F Casas, R Jardí, M Miratvilles… - Archivos de …, 2006 - Elsevier
El déficit de alfa-1-antitripsina (DAAT) es la enfermedad congénita potencialmente mortal
más frecuente en la edad adulta. A pesar de ello, continúa siendo una enfermedad …

Guidelines for the diagnosis and management of α1-antitrypsin deficiency

R Vidal, I Blanco, F Casas, R Jardí, M Miravitlles… - Archivos de …, 2006 - Elsevier
Introduction α1-antitrypsin (AAT) deficiency is the most common potentially fatal hereditary
disease in the adult population. Despite this, the condition continues to be underdiagnosed …

Alpha-1-antitrypsin deficiency

R Bals - Best Practice & Research Clinical Gastroenterology, 2010 - Elsevier
Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder associated with the
development of liver and lung disease. AAT is a 52-kD glycoprotein, produced mainly by …

Alpha-1 Antitrypsin Reduces Severity of Pseudomonas Pneumonia in Mice and Inhibits Epithelial Barrier Disruption and Pseudomonas Invasion of Respiratory …

GB Pott, KS Beard, CL Bryan, DT Merrick… - Frontiers in public …, 2013 - frontiersin.org
Nosocomial pneumonia (NP) is the third most common hospital-acquired infection and the
leading cause of death due to hospital-acquired infection in the US. During pneumonia and …

Advances in managing COPD related to α1‐antitrypsin deficiency: An under‐recognized genetic disorder

TJ Craig, MP Henao - Allergy, 2018 - Wiley Online Library
Abstract α1‐Antitrypsin deficiency (AATD) predisposes individuals to chronic obstructive
pulmonary disease (COPD) and liver disease. Despite being commonly described as rare …

Alpha-1 antitrypsin deficiency: current perspective from genetics to diagnosis and therapeutic approaches

S Santangelo, S Scarlata, M L. Poeta… - Current medicinal …, 2017 - benthamdirect.com
Alpha-1 antitrypsin (A1AT) is a 52-kDa, acute phase glycoprotein encoded by the protease
inhibitor (PI) locus, located on the long arm of chromosome 14 (14q31-32.3). Its structure is …