The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …

Background & Objective: Thioredoxin-interacting protein (TXNIP) also known as thioredoxin
binding protein-2 is a ubiquitously expressed protein that interacts and negatively regulates …

Thioredoxin‐interacting protein (TXNIP) was originally named vitamin D3 upregulated
protein‐1 (VDUP1) because of its ability to bind to thioredoxin (TRX) and inhibit TRX …

We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at
specific loci over two different time points in people with diabetes are associated with …

Diabetes is a risk factor for heart failure and cardiovascular mortality with specific changes to
myocardial metabolism, energetics, structure, and function. The gradual impairment of …

An impaired glucose metabolism, which often leads to the onset of diabetes mellitus (DM), is
a common complication of chronic exposure to exogenous and endogenous glucocorticoid …

Torpor and hibernation are powerful strategies enabling animals to survive periods of low
resource availability. The state of torpor results from an active and drastic reduction of an …

Loss of pancreatic β–cell is a critical factor in the pathogenesis of type 1 diabetes and it also
occurs in type 2. TXNIP (thioredoxin–interacting protein), also known as vitamin D3 …

Given that triple-negative breast cancer (TNBC) lacks specific receptors (estrogen and
progesterone receptors and human epidermal growth factor receptor 2) and cannot be …

First recognized in 1990, takotsubo syndrome (TTS) constitutes an acute cardiac condition
that mimics acute myocardial infarction commonly in the absence of obstructive coronary …