The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

It is well established that muscle contractions during exercise lead to elevated levels of
reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have …

The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

It is well established that contracting muscles produce both reactive oxygen and nitrogen
species. Although the sources of oxidant production during exercise continue to be debated …

The observation that muscular exercise is associated with oxidative stress in humans was
first reported over 30years ago. Since this initial report, numerous studies have confirmed …

High levels of reactive oxygen species (ROS) produced in skeletal muscle during exercise
have been associated with muscle damage and impaired muscle function. Supporting …

Diabetes mellitus has emerged as one of the main alarms to human health in the 21st
century. Pronounced changes in the human environment, behavior and lifestyle have …

Increased reactive oxygen species (ROS) production is crucial to the remodelling that occurs
in skeletal muscle in response to both exercise training and prolonged periods of disuse …

Aging is associated with sarcopenia. The loss of strength results in decreased muscle mass
and motor function. This process accelerates the progressive muscle deterioration observed …

The existence of hypoxia-induced reactive oxygen species (ROS) production remains
controversial. However, numerous observations with a variety of methods and in many cells …