Modulators of ATP-binding cassette transporters

A Looker, BJ Littler, A Choudhury, C Harrison… - US Patent …, 2016 - Google Patents
2013-08-15 Assigned to VERTEX PHARMACEUTICALS INCORPORATED reassignment
VERTEX PHARMACEUTICALS INCORPORATED ASSIGNMENT OF ASSIGNORS …

Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

BD Phenix, LJC Bagnol, GG Brodeur… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
53175129&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Pharmaceutical composition and administrations thereof

W Rowe, P Hurter, C Young, K Dinehart… - US Patent …, 2020 - Google Patents
The present invention relates to pharmaceutical compositions comprising a solid dispersion
of N-[2, 4-Bis (1, 1-dimethylethyl)-5-hydroxyphenyl]-1, 4-dihydro-4-oxoquinoline-3 …

Modulators of ATP-binding cassette transporters

SS Hadida-Ruah, PDJ Grootenhuis, MT Miller… - US Patent …, 2017 - Google Patents
Related US Application Data (60) Continuation of application No. 13/112,115, filed on May
20, 2011, now Pat. No. 8,541,453, which is a division of application No. 1 1/202.278, filed on …

Process for making modulators of cystic fibrosis transmembrane conductance regulator

J DeMattei, AR Looker, B Neubert-Langille… - US Patent …, 2016 - Google Patents
Related US Application Data comprising coupling a carboxylic acid of Formula 2 (63)
Continuation of application No. 13/908,349, filed on Jun. 3, 2013, now Pat. No. 8,765,957 …

Process of producing cycloalkylcarboxamido-indole compounds

GJ Tanoury, C Harrison, BJ Littler, PJ Rose… - US Patent …, 2018 - Google Patents
Int. CI. CO7D 209/40(2006. 01) C070 317/46(2006. 01) C07D 209/12(2006. 01) CO7D
317/60(2006. 01) COZD 405/12(2006. 01) C07C 209/74(2006. 01) C07C 225706 (2006 …

Solid forms of 3-(6-(1-(2, 2-difluorobenzo [d][1, 3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid

A Keshavarz-Shokri, B Zhang, M Krawiec - US Patent 9,150,552, 2015 - Google Patents
The present invention relates to a Substantially crystalline and free solid state form of 3-(6-(1-
(2, 2-difluorobenzod1. 3 dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) …

Processes for producing cycloalkylcarboxamido-pyridine benzoic acids

MT Miller, J McCartney, SS Hadida-Ruah… - US Patent …, 2016 - Google Patents
US9321725B2 - Processes for producing cycloalkylcarboxamido-pyridine benzoic acids -
Google Patents US9321725B2 - Processes for producing cycloalkylcarboxamido-pyridine …

Solid forms of 3-(6-(1-(2, 2-difluorobenzo [d][1, 3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid

A Keshavarz-Shokri, B Zhang, M Krawiec - US Patent 9,434,717, 2016 - Google Patents
The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-
(2, 2-difluorobenzod1, 3dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin 2-yl) …

Solid forms of (R)-1 (2, 2-difluorobenzo [D][1, 3] dioxol-5-yl)-N-(1-(2, 3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) …

A Keshavarz-Shokri, B Zhang, TE Alcacio… - US Patent …, 2018 - Google Patents
The present invention relates to solid forms of (R)-1-(2, 2 difluorobenzo [d][1, 3] dioxol-5-yl)-
N-(1-(2, 3-dihydroxypro pyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-in dol-5-yl) …